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Exploring the Effect of Perioperative Oxycodone on Alleviating Postoperative Shoulder Pain Following Hepatic Tumor Surgery: A Prospective, Randomized, Double-Blind, Parallel-Controlled Study

Exploring the Effect of Perioperative Oxycodone on Alleviating Postoperative Shoulder Pain Following Hepatic Tumor Surgery: A Prospective, Randomized, Double-Blind, Parallel-Controlled Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102277
Enrollment
Unknown
Registered
2025-05-12
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative shoulder pain after hepatic tumor surgery

Interventions

Control group:Intravenous administration of 10 µg sufentanil, PCIA(100mg flurbiprofen +100ug sufentanil combined with normal saline to 200ml)
Oxycodone group:Intravenous administration of 10 mg oxycodone, PCIA(100mg flurbiprofen +50ug sufentanil +50mg oxycodone combined with normal saline to 200ml)

Sponsors

Fudan University Shanghai Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Aged 18–70 years; 2.ASA I–III; 3.Undergoing hepatic tumor surgery; 4.BMI <35.

Exclusion criteria

Exclusion criteria: 1)Inability to provide informed consent or communicate; 2)History of opioid abuse; 3)Coagulopathy; 4)Contraindications to epidural anesthesia; 5)Pre-existing shoulder pain prior to surgery; 6)Child-Pugh class C liver function; 7)History of shoulder arthritis.

Design outcomes

Primary

MeasureTime frame
Shoulder pain scores during the first 2 postoperative days;The incidence of shoulder pain during the first 2 postoperative days;

Secondary

MeasureTime frame
Incisional pain on the first postoperative day.;Shoulder pain score on the first postoperative day.;Incisional pain on the second postoperative day.;Shoulder pain score on the second postoperative day.;Quality of Recovery (QoR) score on postoperative day 2;The duration of surgery;The patient's pain score in the PACU;Patient's medication use in the PACU;Record the number of successful attempts at patient-controlled analgesia (PCA) activations postoperatively.;Record the number of failed attempts at patient-controlled analgesia (PCA) activations postoperatively.;Dizziness related to oxycodone;Nausea related to oxycodone;Vomiting related to oxycodone;

Countries

China

Contacts

Public ContactZhang Jun

Fudan University Shanghai Cancer Center

snapzhang@aliyun.com+86 138 1715 3025

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026