Osteoarthritis
Conditions
Interventions
Propofol group (group P):induces anesthesia with propofol 2 mg/kg
Ciprofol group (group C):induces anesthesia with ciprofol 2 mg/kg
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for knee or hip joint replacement surgery in this hospital; 2. ASA classification I-III; 3. Age >= 65 years, regardless of gender; 4. BMI between 18 kg/m^2 and 26 kg/m^2; 5. No communication barriers and willingly participating in this study.
Exclusion criteria
Exclusion criteria: 1. History of cardiac and cerebral disorders; 2. Untreated stage 2 and stage 3 hypertension; 3. Hepatic and renal insufficiency; 4. Known allergies to eggs, soybean products, propofol, and cirrhosis; 5. Participation in other clinical trials within the past month; 6. Other reasons deemed by the researcher that make the participant unsuitable for inclusion in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative average pump volume of propofol per kilogram of body weight per unit time;Wake time;Extubation time;Intraoperative blood concentration of propofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative mean pressure fluctuation;Rate and dose of vasoactive drugs;Postoperative modified Aldrete score; | — |
Countries
China
Contacts
Public ContactChen Xiaoxiang
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed