Class II obesity combined with obesity-related comorbidities including type 2 diabetes, hypertension, heart disease, and sleep apnea, and Class III obesity.
Conditions
Interventions
Propofol detection group:None
Sponsors
Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old,=40kg/m ^ 2 or BMI>=35kg/m ^ 2, and there is at least one obesity related complication (type 2 diabetes, hypertension, heart disease, sleep apnea, osteoarthritis, gout, depression, etc.); 5. Agree to participate in this study and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this study; 2. Severe liver dysfunction (Child Pugh C grade); Severe renal dysfunction (undergoing dialysis before surgery); ASA rating>=IV; 3. Propofol allergy; 4. Other researchers or supervising doctors consider it inappropriate to participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration of propofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS;Heart rate;Pulse oxygen saturation;Mean arterial pressure;Rate of excessive sedation;Intraoperative awareness incidence; | — |
Countries
China
Contacts
Public ContactJinhua Bo
Nanjing University Medical School affiliated Gulou Hospital
Outcome results
None listed