major spine surgery
Conditions
Interventions
The Remimazolam Group:Remimazolam sevoflurane maintenance combined with flumazenil antagonism
The Propofol Group:propofol sevoflurane maintenance not combined with flumazenil antagonism
Sponsors
The Second Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18-65 years old, gender not limited, scheduled for open surgery in spinal surgery (expected anesthesia duration >= 3 hours); 2. ASA grades I-III; 3. 18Kg/m^2 <= BMI <= 30kg/m^2; 4. Can understand the procedures and methods of this trial, willing to strictly follow the clinical research protocol to complete this trial, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Difficult airways, pulmonary infections, and acute asthma; 2. Patients with recent history of myocarditis, endocarditis, heart failure, or recent thrombosis (= 160mmHg and/or diastolic blood pressure >= 90mmHg), diabetes (random blood glucose >= 11.1 mmol/L); 4. Individuals allergic to benzodiazepines, opioids, propofol, or muscle relaxants, with a history of epilepsy, long-term alcohol dependence, and long-term drug abuse; 5. Patients with a history of previous mental illness or use of psychotropic drugs, cognitive impairment, or consciousness disorders; 6. Abnormal liver function, AST and/or ALT >= 2.5 x upper limit of normal, TBIL >= 1.5 x upper limit of normal; 7. Abnormal renal function, urea or urea nitrogen >= 1.5 times the upper limit of normal, and blood creatinine above the upper limit of normal; 8. Expected bleeding volume is greater than 800ml; 9. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of delayed emergence; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time to emergence;Time for BIS to recover to 80;the time to obey demand;the time to extubation;PACU dwell time ;emergence agitation;QoR15; | — |
Countries
China
Contacts
Public ContactDai Ruping
The Second Xiangya Hospital, Central South University
Outcome results
None listed