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The effect of esketamine on peripheral vascular resistance in elderly patients during the induction period of anesthesia:A single-center,double-blind,prospective randomized controlled trial

The effect of esketamine on peripheral vascular resistance in elderly patients during the induction period of anesthesia:A single-center,double-blind,prospective randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102259
Enrollment
Unknown
Registered
2025-05-12
Start date
2025-05-15
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic changes in elderly

Interventions

Observers:Induction with ketamine
control group:Induction with equal amount of physiological saline solution

Sponsors

Central Theater General Hospital of the Chinese People's Liberation Army
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 60 years old; 2. Planned elective surgery under general anesthesia; 3. American Society of Anesthesiologists rating I-II; 4. New York Heart Association Heart Function Score Level I; 5. There are no contraindications related to the medication used in this study; 6. Sign informed consent form

Exclusion criteria

Exclusion criteria: 1. Merge severe cardiovascular diseases (acute heart failure, myocardial infarction, etc.); 2. Patients at serious risk of elevated blood pressure or intracranial pressure; 3. Combined neurological disorders (such as preeclampsia and eclampsia) or a history of severe mental disorders; 4. History of liver and kidney dysfunction; 5. Patients who are allergic to the drugs used in the research institute; 6. Participants in other clinical trials in the past 3 months

Design outcomes

Primary

MeasureTime frame
snuff-box resistive index, SBRI;blood pressure;Heart Rate;SpO2;

Secondary

MeasureTime frame
The incidence of adverse reactions;

Countries

China

Contacts

Public ContactGan Guosheng

Central Theater General Hospital of the Chinese People's Liberation Army

526193186@qq.com+86 133 9719 2799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026