Postoperative delirium
Conditions
Interventions
Group:H-H:Maintain EtCO2 40-45 mmHg and FiO2 80% during surgery
Group:H-L:Maintain EtCO2 40-45 mmHg and FiO2 30% during surgery
Group:L-L:Maintain EtCO2 30-35 mmHg and FiO2 30% during surgery
Group:L-H:Maintain EtCO2 30-35 mmHg and FiO2 80% during surgery
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=65 years; 2. ASA physical status I-III; 3. Patients scheduled for elective abdominal, urological, or orthopedic surgeries under general anesthesia. 4. Expected extubation with operation time over one hour;
Exclusion criteria
Exclusion criteria: 1. Combined heart diseases (such as NYHA cardiac function classification >= grade 3, coronary heart disease, heart valve disease (moderate to severe)); 2. Central nervous system diseases and mental disorders; 3. History of treatment with antidepressants or sedatives; 4. Unable to cooperate with the researcher for any reason; 5. Enrolled in other clinical studies;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of unplanned transfer to the ICU within 7 days after surgery;Postoperative hospital stay;Days at home within 30 days post-surgery (DAH30);Pulmonary complications from postoperative period to discharge;Intraoperative hypoxemia;The incidence of intraoperative adverse cardiovascular events;The incidence of intraoperative cerebral deoxygenation saturation;The incidence of re-intubation within 7 days after surgery; | — |
Countries
China
Contacts
Public ContactHai Yu
West China Hospital of Sichuan University
Outcome results
None listed