Complicated Wounds
Conditions
Interventions
Intervention Group:Participants will receive a combination of Platelet-Rich Plasma (PRP) therapy and Electrical Muscular Stimulation (EMS) in addition to standard wound care. PRP will be prepared usin
Control Group:Participants will receive standard wound care, including cleaning, dressing changes, debridement if necessary, and pressure offloading where appropriate.
Sponsors
Combined Military Hospital Kohat
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: • Participants must be aged 18 years or older. • Participants should have chronic or complicated wounds, including diabetic foot ulcers, pressure ulcers, venous leg ulcers, or post-surgical or trauma-related wounds, that have not shown significant healing after at least 4 weeks of conventional wound care. • The wounds must have been present for at least 4 weeks but less than 12 months and have a minimum surface area of 1 cm². • Participants must be in stable general health, as determined by the principal investigator, and not have any contraindications for PRP or EMS therapies, such as active infection, uncontrolled diabetes, or severe cardiovascular disease. • Participants must be capable of providing written informed consent, indicating understanding of the study procedures and potential risks.
Exclusion criteria
Exclusion criteria: • Participants will be excluded if they are under the age of 18, have active infections at the wound site, or have a history of severe allergic reactions to platelet-rich plasma (PRP) therapy or electrical muscular stimulation (EMS). • Individuals with severe cardiovascular, renal, or hepatic conditions, or those with uncontrolled diabetes or autoimmune diseases that may impair wound healing, will also be excluded. • Participants who are pregnant or breastfeeding, or those with a known history of cancer or metastatic disease, will not be eligible. • Individuals who are receiving immunosuppressive therapy or anticoagulants (except low-dose aspirin) or have a history of bleeding disorders will be excluded. • Any patient who has undergone prior wound care treatments that significantly alter healing, such as skin grafting or other advanced regenerative treatments, within the last 6 months will not be included. • Additionally, participants who are unable or unwilling to provide informed consent or comply with study protocols will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound length, width, area, and perimeter will be calculated by tracing the wound using specialized wound measurement software that is imito; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analog Scale ;Wound-QoL questionnaire; | — |
Countries
Pakistan
Contacts
Public ContactSyed Tameem Ul Hassan
Combined Military Hospital Kohat, KPK, Pakistan
Outcome results
None listed