Skip to content

Association between Corticospinal Tract Hypoperfusion and Unexplained Early Neurological Deterioration After Intravenous Thrombolysis

Association between Corticospinal Tract Hypoperfusion and Unexplained Early Neurological Deterioration After Intravenous Thrombolysis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102224
Enrollment
Unknown
Registered
2025-05-12
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic stroke

Interventions

Case group:None
Control group:None

Sponsors

Haiyan People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Received IVT within 9 h after the onset; 2.Underwent baseline CT perfusion (CTP) before IVT.

Exclusion criteria

Exclusion criteria: 1.Had cerebral arenchymal hemorrhage (PH) within 24 h, which was defined as a hematoma in = 30% of the infarcted area with some slight space-occupying effect or blood clots in > 30% of the infarcted area with a substantial space-occupying effect; 2.Had malignant brain edema within 24 h, which was defined as concomitant imaging which showed brain swelling and midline shift which were associated with worsening of consciousness; 3.Had early recurrent stroke within 24 h, which was defined as the new neurological symptoms along with the evidence of corresponding ischemic lesions on follow-up cranial CT or MRI, which suggested the involvement of initially unaffected vascular area ; 4.Finally, if they had failed image post-processing due to movement artifacts or huge previous lesions.

Design outcomes

Primary

MeasureTime frame
Unexplained early neurological deterioration;

Secondary

MeasureTime frame
Unfavorable outcome at 3 months;

Countries

China

Contacts

Public ContactDanfeng Zhang

Haiyan People's Hospital

zdf19850911@vip.sina.com+86 137 3646 0670

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026