Acute ischemic stroke
Conditions
Interventions
Experimental group:Using non-invasive percutaneous auricular vagus nerve stimulator, stimulate the patients ear vagus nerve branch mainly distribution area, anatomical localization mainly for the auri
auricular electrodes are fixed in the distribution area of the vagus nerve in the ear cavity, and the power is turned on
the frequency is set at 25Hz 500ms with an interval of 30 s. Treatment time and duration: 1 treatment in the morning and 1 treatment in the evening every day, each time for 30 minutes, 7 consecutive d
Control group:The operation was the same as in the experimental group, but no stimulation was performed. No other brain stimulation treatments were performed, and the rest of the treatment measures fo
Sponsors
The First Affiliated Hospital of Chengdu Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female aged >18 years with onset within 24 hours; 2. Diagnosed with acute ischemic stroke according to the diagnostic criteria in the Chinese Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke 2023, with 10 points <= NIHSS score <= 25 points; 3. cTn level within 24 hours is higher than the 99th percentile of the specificity reference line; 4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Modified Rankin Scale (mRS) =1 before the onset of symptoms. 2. Patients with a clear history of previous cardiac disease, including coronary atherosclerotic heart disease, second- or third-degree atrioventricular block, and left ventricular systolic dysfunction. 3. Patients with severe neurological diseases, including epilepsy, encephalitis, and moderate-to-severe dementia. 4. Patients with severe cardiac, hepatic, or renal dysfunction, or patients in the terminal stage of disease, or patients with malignant tumors or severe hematologic diseases, or patients with immune system diseases, or patients with unstable vital signs. 5. Undergoing surgical debridement intervention. 6. Currently participating in any other interventional clinical trial. 7. Contraindications to transcutaneous auricular vagal nerve stimulation, e.g., cochlear implants, deep brain stimulation therapy. 8. Pregnant or planning a pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dynamics of cardio-enzymology; | — |
Countries
China
Contacts
Public ContactLan Wen
The First Affiliated Hospital of Chengdu Medical College
Outcome results
None listed