None
Conditions
Interventions
Group P:Anesthesia will be induced and maintained using total intravenous anesthesia with propofol as the main drug
Group C:Anesthesia will be induced and maintained using total intravenous anesthesia with ciprofol as the main drug
Group R:Anesthesia will be induced and maintained using total intravenous anesthesia with remimazolam as the main drug
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for transapical TAVR surgery under general anesthesia;
Exclusion criteria
Exclusion criteria: 1.Patients in a coma, with hypovolemia or shock and using vasoactive drugs; 2.Patients with combined mental disorders, long-term use of psychotropic drugs or cognitive dysfunction; 3.Patients with a history of alcohol abuse or drug abuse within the past two years; 4.Patients who are planned to be sent to the ICU with a tracheal tube; 5.Patients with contraindications to benzodiazepines, opioids, propofol, muscle relaxants or study drugs; 6.Patients unable to participate in the research for any reason;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR15- score on the first day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital stay;The QoR-15 scores on the 2nd and 3rd days after surgery;The incidence of PACU delirium;Postoperative nausea and vomiting;Pulmonary complications within 7 days after surgery;Postoperative tracheal extubation time;The incidence of intraoperative hypotension;Days at home within 30 days post-surgery;The mortality rate within 30 days after surgery; | — |
Countries
China
Contacts
Public ContactQirong Sun
West China Hospital of Sichuan University
Outcome results
None listed