Helicobacter pylori infection
Conditions
Interventions
Group A: 14-day Tigorazan triple therapy:Tigorazan 50mg twice a day
Amoxicillin 1000mg twice a day
Doxycycline 100mg twice a day
Group B: 14-day tigorazan bismuth-containing quadruple therapy:Tigorazan 50mg twice a day
Amoxicillin 1000mg twice a day
Doxycycline 100mg twice a day
Bismuth potassium citrate 600mg twice a day
Sponsors
Wenzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-70 years old, male or female. (2) Helicobacter pylori infection (13C/14C urea breath test positive) (3) Patients who had not previously received Helicobacter pylori eradication therapy
Exclusion criteria
Exclusion criteria: (1) Serious underlying diseases, such as liver insufficiency (AST or ALT greater than 3 times the normal value), renal insufficiency (Cr>=2.0mg/dL or GFR = 75%) (2) Those who are not willing to take contraceptive measures during pregnancy, lactation and the test (3) Active bleeding of digestive tract (4) Test drug allergy history (5) Use history of bismuth, antibiotics, PPI and other drugs within 4 weeks (6) other behaviors that may increase the risk of the disease, such as alcohol and drug use (7) Unable or unwilling to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety, compliance, and adverse reactions; | — |
Countries
China
Contacts
Public ContactPan Jie/Zhou Qingjie
Wenzhou Central Hospital
Outcome results
None listed