Patient-controlled intravenous analgesia after video-assisted thoracic surgery
Conditions
Interventions
Oliceridine bolus group (group OA):For patients in group OA, the bolus dose will be set at 0.35 mg with a lockout interval of 10 minutes.
Oliceridine background infusion plus bolus group (group OB):Group OB will be administered a supplementary background infusion of 0.1 mg/h in addition to the protocol-specified bolus doses, whereas gro
Sufentanil background infusion plus bolus group (group SF):We will set the bolus dose of sufentanil at 1.4 µg, with a background infusion of 0.4 µg and a lockout interval of 10 minutes.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 65 and 79 years; 2. American Society of Anesthesiologists (ASA) physical status classification ranging from II to III; 3. BMI of 18-30 kg/m2; 4. Patients who scheduled for elective VATS Lobectomy or Segmentectomy
Exclusion criteria
Exclusion criteria: 1. Hepatitis, renal failure, severe cardiovascular or cerebrovascular disease, history of chronic pain, or psychiatric illness; 2. Allergy to study drugs; Long-term use of sedatives, analgesics or other drugs; 3. Unable to read, write or understand Chinese; 4. Unwillingness to use PCIA or refusal to participate in research; 5. Intraoperative blood loss >=800 ml; 6. Transfer to intensive care unit (ICU) after operation; 7. Failure to extubate within 2 hours after surgery. 8. The surgeon changed the operation plan; 9. Medication was not used according to the study protocol; 10. No monitoring records or incomplete CRF records; 11. Patients voluntarily withdrew from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of satisfactory analgesia and lightest vomiting when coughing within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of satisfactory analgesia and lightest vomiting at rest within 3 days after surgery;Patient satisfaction with analgesia;Other adverse reactions of analgesic drugs;QoR-15;Duration of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactZhongyun Wang
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed