Major depressive disorder, cognitive impairment, insomnia
Conditions
Interventions
Intervention Group 1:Olfactory (such as lavender) interventions are carried out during sleep (SWS).Sleep monitoring and brain function tests (MRI, near-infrared) before and after sleep, as well as cog
Intervention Group 2:Cognitive training is conducted under background odors before going to bed, and then olfactory (such as lavender) intervention is carried out during sleep (SWS)..Sleep monitoring
Control:No odor intervention was conducted. Only sleep monitoring, brain function examinations before and after sleep (MRI, near-infrared), and cognitive training tests were carried out
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for healthy individuals: (1) Healthy adults (aged 18-60 years old); (2) No olfactory disorders or sleep problems Disorder or mental illness; (3) Voluntarily participate in the experiment and sign the informed consent. Inclusion criteria for MDD patients: (1) Patients diagnosed with MDD by DSM-5 (aged 18-60 years); (2 No olfactory disorder; (3) Voluntarily participate in the experiment and sign the informed consent. Inclusion criteria for MCI/ dementia patients: 1) Patients with cognitive impairment screened by MMSE (MMSE<24); (2) No olfactory disorder; (3) Voluntarily participate in the experiment and sign the informed consent. Inclusion criteria for patients with insomnia: (1) Patients diagnosed with insomnia by DSM-5 (aged 18-60 years); (2) No Have olfactory disorders; (3) Voluntarily participate in the experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Those with cognitive impairment or long-term use of drugs that affect cognition (such as antipsychotic drugs) Sedative-hypnotic drugs, etc. (2) Those who are allergic to the test odor; (3) Those who have recently attempted suicide or have suicidal thoughts; (4) In reality Having worked night shifts within 6 weeks before the test or having combined factors or diseases that affect sleep, such as OSA, etc. (5) Severe cardiopulmonary diseases Liver and kidney diseases, etc. (6) Unable to cooperate in completing the cognitive test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain function;Cognitive function;Biomarker;Affective; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dream content; | — |
Countries
China
Contacts
Public ContactRong Ren
West China Hospital Sichuan University
Outcome results
None listed