Autistic spectrundisorder
Conditions
Interventions
Dose escalation group:Nasal spray induced pluripotent stem cell-derived exosomes
treatment group:Nasal spray induced pluripotent stem cell-derived exosomes
control group:Nasal spray saline placebo
Sponsors
The First Medical Center of the Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1.The diagnostic criteria for ASD were consistent with the second edition of the Autism Diagnostic Observation Scale (ADOS-2) : 7 points, >=5 years old ADOS score >8 points; 2. Age 3-8 years old, male or female; 3. No known immune deficiency diseases, blood routine, liver, kidney, heart, lung no major functional abnormalities; 4.Clinical study participants and/or guardians can fully understand the informed consent content of this study and voluntarily sign the informed consent
Exclusion criteria
Exclusion criteria: 1.Patients with tumors or tumor history (including hematologic tumors and solid tumors); 2.previous history of severe allergic reaction, blood product allergy; 3.Autism and other mental disorders other than autism spectrum disorders due to active epilepsy, cerebrovascular disease or brain trauma; 4.Situations that other researchers consider inappropriate to be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| social responsiveness scale;Vineland scale score; | — |
Countries
China
Contacts
Public ContactYang Guang
The First Medical Center of the Chinese PLA General Hospital
Outcome results
None listed