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Effects of penehyclidine hydrochloride combined with acupuncture on nausea, vomiting and early quality of recovery after thyroidectomy: a randomized, double-blind, 2×2 factorial design trial

Effects of penehyclidine hydrochloride combined with acupuncture on nausea, vomiting and early quality of recovery after thyroidectomy: a randomized, double-blind, 2×2 factorial design trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102180
Enrollment
Unknown
Registered
2025-05-09
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting

Interventions

Penehyclidine hydrochloride combined with postoperative acupuncture treatment group (PA group):Penehyclidine plus acupuncture
Normal saline combined postoperative acupuncture treatment group (NA group):acupuncture
Penehyclidine hydrochloride combined with pseudoacupuncture treatment group (PC group):penehyclidine
Normal saline combined with sham acupuncture treatment group (NC group):None

Sponsors

The Fourth Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) Selected patients who underwent elective thyroidectomy in our hospital; 2) American Society of Anesthesiologists (ASA) grade I to III; 3) Age 18-65 years old, body mass index (BMI) 18-28 kg/m^2; 4) Agree to participate in the study and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1) Infection or rupture at acupuncture points; 2) Patients with cervical spondylosis and insufficient cerebral blood supply; 3) Patients with severe insufficiency of heart, liver, lung and kidney function; 4) Patients with immune system, blood system diseases and coagulation dysfunction. Patients with glaucoma, hypertrophy of prostate and hyperthermia; 5) There are acupuncture-related contraindications; 6) Patients requiring radical neck dissection; 7) PONV or motion sickness history, smoking history; 8) Take antiemetic or anticholinergic drugs before surgery.

Design outcomes

Primary

MeasureTime frame
Incidence of postoperative nausea and vomiting;Occurrence time of postoperative nausea and vomiting;

Secondary

MeasureTime frame
Dizziness and headache within 48 hours after surgery;Quality of recovery within 48 hours after surgery;Postoperative sleep quality;Sore throat;Patient satisfaction;

Countries

China

Contacts

Public ContactHuaqin Liu

Department of Anesthesia, the Fourth Hospital of Hebei Medical University

sjzlhq@163.com+86 185 3111 8952

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026