None
Conditions
Interventions
Night shift group:The night shift group will conduct a 10-day simulated night shift study, including a 3-day adaptation period, a 4-day continuous night shift period, and a 3-day recovery period. Duri
Sleep restriction group:The sleep restriction group undergoes a 10-day trial, including a 3-day adaptation period, 4 consecutive days of sleep restriction, and a 3-day recovery period. During the slee
Normal control group:The normal control group will allow the subjects' usual nighttime sleeping habits and ensure 8 hours of sleep opportunity.
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 44 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-44 years old, gender is not limited; 2.BMI18-27kg/m^2; 3. No history of shift work in the past 1 year, no late sleep and late wake up in the past 2 months, regular bedtime (21:00-23:00), sleep duration of 7-9 hours and no more than 1 hour of actigraphy monitoring fluctuation in a week.
Exclusion criteria
Exclusion criteria: 1. Currently smoking or drinking; 2. Chronic underlying diseases such as hypertension, diabetes, heart disease or other major physical diseases; 3. Pregnant or lactating women; 4. Mental disorders such as anxiety disorders, depressive disorders, bipolar disorders, schizophrenia, and post-traumatic stress disorder; 5. Sleep disorders such as insomnia, sleep apnea syndrome, restless legs syndrome, periodic leg movements, etc.; 6. Currently taking drugs related to mental illness or sleep disorders, and oral contraceptives and other drugs that may interfere with the study endpoint; 7. Have a history of bariatric surgery; 8. Those who have severe claustrophobia, or have metal or magnetic implants in their bodies; 9. Subjects who are undergoing other clinical studies; 10. Disagree to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood metabolomic changes;Functional activity in different brain regions measured by task-based functional magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Generalized anxiety disorder scale score;Depression screening scale score;Beck Suicidal Ideation Scale score;Barratt Impulsivity Scale-11 score;Insomnia severity index, ISI;Early morning and evening type scale - 5-item score;Epworth Sleepiness Scale score;EMA self-assessment module;Energy intake;Energy expenditure;Thermic effect of food;Physical activity;Inflammomics;Proteomics;24h urinary catecholamines;Visual analogue scale, VAS;Neurocognitive tests;Peripheral blood markers; | — |
Countries
China
Contacts
Public ContactJihui Zhang
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed