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Early accurately prediction of the efficacy of advanced triple negative breast cancer immunotherapy based on spatio-temporal heterogeneity features of multi-modal MRI

Early accurately prediction of the efficacy of advanced triple negative breast cancer immunotherapy based on spatio-temporal heterogeneity features of multi-modal MRI

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500102170
Enrollment
Unknown
Registered
2025-05-09
Start date
2024-01-25
Completion date
Unknown
Last updated
2025-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer

Interventions

Gold Standard:After the course of neoadjuvant therapy, surgical resection was performed, and pathological complete response (pCR) was evaluated using postoperative pathology as the gold standard. Prog
Index test:All patients underwent standard breast multimodal MRI scanning before treatment (T0) and at the end of 2-3 courses (T1). Standard breast MRI sequences include axial T1WI, axial T2WI fat sup

Sponsors

Guangzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 90 Years

Inclusion criteria

Inclusion criteria: Female, 30-90 years old; Patients with pathologically confirmed invasive breast cancer were collected, the clinical, MRI and pathological data of all enrolled patients were collated, and the prognosis of patients was tracked. Enrollment conditions:1. pathologically confirmed invasive breast cancer; 2. Neoadjuvant therapy; 3. There are standard MRI images of the breast before treatment (T0) and at the end of the 2nd-3rd course (T1); 4. Complete clinical data.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1. Primary or recurrent breast lesions have been surgically removed; 2. Discontinuation of medication due to severe side effects; 3. Lack of complete clinical imaging data.

Design outcomes

Primary

MeasureTime frame
Before treatment - MRI examination;Early post-treatment - MRI examination;

Countries

China

Contacts

Public ContactWenjie Tang

Guangzhou First People's Hospital

eywenjietang@scut.edu.cn+86 134 3029 8827

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026