Tic disorder
Conditions
Interventions
Immunosusceptible group (Study One):Cytokine assays
Normal group (Study One):Cytokine assays
Treatment group (Study Two):Transcranial direct current stimulation
Control group (Study Two):Pseudo-stimulation of transcranial direct current stimulation
Sponsors
the Affiliated Brain Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Study 1: (1) Patients who attended the outpatient clinic of the Children's Center of Nanjing Brain Hospital and met the DSM-5 CTD/TS diagnostic criteria; (2) Age 4~18 years old; (3) Participants and their parents have signed a written informed consent form; (4) Right hand. Study 2: (1) Patients who were admitted to the Children's Mental Health Research Center of the Brain Hospital of Nanjing Medical University and met the DSM-5 CTD/TS diagnostic criteria; (2) Age 6~18 years old; (3) Previous EEG examination is normal (official report issued by a tertiary hospital); (4) Patients who are on medication to control tics, as long as the dose is stable for at least six weeks before participation and there is no planned change during the course of the study, can also be included; (5) Participants and their parents have signed written informed consent; (6) Right hand.
Exclusion criteria
Exclusion criteria: Study 1: (1) Presence of severe mental disorders, such as schizophrenia, bipolar disorder, major depressive disorder, and severe mental retardation; (2) Have neurological diseases and serious physical diseases. Study 2: (1) Contraindications to tDCS (including: implantable electronic devices in vivo, implanted metal cranial devices, history of traumatic brain injury, scalp lesions at the proposed electrode site, history of epilepsy); (2) Presence of severe mental disorders, such as schizophrenia, bipolar disorder, severe depression, and severe mental retardation; (3) Have a history of neurological diseases and serious physical diseases; (4) Those who cannot cooperate with the completion of the test and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine;Yale Global Tic Severity Scale;Cytokines;Resting-state brain network analysis;Yale Global Tic Severity Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age of onset;Course of disease;Children's Sleep Habits Questionnaire;Depression Self-rating Scale for Children;The Screen for Child Anxiety Related Emotional Disorders;Swanson, Nolan, and Pelham Questionnaire — Version IV, SNAP-?;Cognitive Flexibility Scale;Parenting Stress Index - Short Form; | — |
Countries
China
Contacts
Public ContactKe Xiaoyan
the Affiliated Brain Hospital of Nanjing Medical University
Outcome results
None listed