Acute respiratory distress syndrome
Conditions
Interventions
High lung recruitability group:None
Low lung recruitability group:None
Sponsors
Zhongda Hospital of Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) patients aged >=18 and <=80 years; (2) patients with invasive mechanical ventilation in a single prone position for a period of time greater than or equal to 12 hours; (3) patients or their family members signing an informed consent form.
Exclusion criteria
Exclusion criteria: (1) pregnant or lactating women; (2) severe shock that could not be effectively corrected in the short term; (3) pre-existing severe cardiac insufficiency or pulmonary hypertension; (4) inability to obtain competent cardiac ultrasound images for various reasons; (5) concurrent ECMO therapy in the prone position; (6) patients with non-resuscitatable terminal status or expected to die within 24h.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulmonary artery systolic pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tricuspid annulus plane systolic excursion;Tricuspid annulus plane systolic excursion/pulmonary artery systolic pressure;central venous pressure;Inferior vena cava;Right ventricular area change fraction;Right ventricular peak systolic velocity(s’);left ventricular ejection fraction;Left ventricular outflow tract velocity time integral;Ventilation and blood flow match;dead space;shunt;Ventilation Inhomogeneity Index;oxygenation index;partial pressure of arterial blood carbon dioxide;lactic acid;driving pressure;Static compliance of the respiratory system;recruitment-inflation index;positive end-expiratory pressure;Inhaled oxygen concentration;right-to-left transverse diameter ratio;acidity and alkalinity(PH);partial pressure of oxygen in arterial blood;norepinephrine dosage;mean arterial pressure;systolic blood pressure;diastolic blood pressure;heart rate; | — |
Countries
China
Contacts
Public ContactChun Pan
Sichuan Provincial People's Hospital/ Zhongda Hospital of Southeast University
Outcome results
None listed