Traumatic brain injury, cerebrovascular accident and Craniocerebral tumor surgery
Conditions
Interventions
Remimazolam group:The sedative drug is remimazolam tosylate at a loading dose of 0.2 mg/kg and a maintenance dose of 1.0 mg/kg/h.
Propofol group:The sedative drug is propofol at a loading dose of 0.3 mg/kg/h and a maintenance dose of 1.2 mg/kg/h.
Sponsors
Beijing tiantan hospital, capital medical university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The primary disease is traumatic brain injury, cerebrovascular accident, or postoperative craniocerebral tumor; 2. After joint evaluation by neurosurgeons and ICU physicians, there is a need to establish a long-term artificial airway; the relevant personnel will not participate in the treatment of the method of tracheal incision; 3. Aged 18 or above; 4. No obvious intracranial hypertension; 5. The family member signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Infection of the skin and soft tissue in the anterior neck; 3. History of lesion or surgery in the anterior cervical region; 4. Instability of the cervical spine, such as fractures or dislocations; 5. Severe dysfunction of the coagulation system; 6. BMI>=28kg/m^2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension; | — |
Countries
China
Contacts
Public ContactLi Hongliang
Beijing tiantan hospital, capital medical university
Outcome results
None listed