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Comparison of efficacy and safety of different anticoagulants in dual plasma cytokine adsorption system (DPCAS) in the treatment of liver failure

Comparison of efficacy and safety of different anticoagulants in dual plasma cytokine adsorption system (DPCAS) in the treatment of liver failure

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102105
Enrollment
Unknown
Registered
2025-05-08
Start date
2025-05-16
Completion date
Unknown
Last updated
2025-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver failure

Interventions

Sponsors

Affiliated Hospital of Guangdong Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Between 18 and 65 years old; 2. AST/ALT>20 times ULN; 3. TBIL>10 x ULN; 4. PT-INR> 1.5; 5. PLT>50×10^9/L; 6. Liver imaging showed no liver cancer;

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating women; 2. Patients with HIV infection or other immunodeficiency diseases; 3. Patients with diabetes, autoimmune diseases, infarction caused by cardiovascular and cerebrovascular accidents, history of organ transplantation and other organs Dysfunction or failure; 4. Patients with active bleeding, diffuse intravascular coagulation, thrombosis or thrombotic disease; 5. Those who cannot comply with the study arrangement and sign the informed consent; 6. Can not return to the hospital regularly according to the study plan and follow up visitors; 7. Other conditions that the researchers judged were not suitable for inclusion;

Design outcomes

Primary

MeasureTime frame
Coagulation function;MELD score;

Secondary

MeasureTime frame
Adverse reactions (e.g. local hypersensitivity, extubation, local bleeding, shock, death, etc.);Renal function;Blood routine examination;Liver function;

Countries

China

Contacts

Public ContactWei Deng

Affiliated Hospital of Guangdong Medical University

dwgdmc@163.com+86 159 7595 6972

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026