Moderate to severe acne with the following symptoms: Acne is obvious, including numerous pimples, inflammatory papules, or pustules
Conditions
Interventions
Treatment group:Prednisone is reduced within 4 weeks with oral isotretinoin softgels (10 mg to 20 mg) plus low-dose prednisone tablets (10 mg to 20 mg) depending on resolution of inflammatory rash.
Positive control group:Oral doxycycline 100mg-200mg is administered sequentially over 4 weeks with oral isotretinoin (10mg-20mg).
Sponsors
Qingxian People's Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Those who meet the diagnostic criteria for moderate or severe acne vulgaris; 2. Aged between 16 and 45 years old, no history of serious medical diseases, mental illnesses and severe malignant skin tumors, and female patients are not in the stage of trying to conceive, pregnant or breastfeeding; 3. Those who have not received oral and topical treatment for acne within 1 month, or who have received treatment but the effect is not obvious; 4. Comply with the treatment plan, be able to have regular follow-up visits, cooperate with the collection of photos before and after treatment, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients who are pregnant or trying to be pregnant ; 2.Explosive acne and acne-like rash; 3.Serious infection and liver and kidney function injury indicated by blood routine; 4.Mental abnormality ? oral drug allergy or intolerance; 5.Other reasons could not complete the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin symptom grading score; | — |
Countries
China
Contacts
Public ContactZhang Luo
Qingxian People's Hospital
Outcome results
None listed