Rotator cuff injury
Conditions
Interventions
Group C:An equal dose of saline solution
S1 group:Esketamine 0.5mg/kg was administered before induction and esketamine 0.25mg/kg/h intraoperatively was continuously pumped intravenously to sutures.
S2 group:Esketamine 0.25mg/kg was administered before induction and esketamine 0.125mg/kg/h intraoperatively was continuously pumped intravenously to sutures.
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged>=18 years; 2.American Society of Anesthesiologists (ASA) physical status I–II; 3.BMI 18-30; 4. Arthroscopic rotator cuff repair surgery under general anesthesia is planned to be elective; 5. Have the ability to read and write, and can sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.An established mental illness; 2.Severe disorders affecting consciousness or mental health, such as schizophrenia, mania, bipolar disorder, psychosis, and cognitive dysfunction; 3.A history of chronic pain or opioid abuse prior to surgery; 4.drug and/or alcohol abuse within the last 3 months, defined as consuming an average of more than 2 units of alcohol per day (1 unit =360 ml of 5% beer or 45 ml of 40% liquor or 150 ml of wine); 5.Postoperative admission to the ICU; 6.Allergy to the active ingredient or excipient of esketamine hydrochloride injection; 7.Contraindications for esketamine use including a risk for serious rise in blood pressure or intracranial pressure, high intraocular pressure (glaucoma), poorly controlled hypertension (resting systolic blood pressure greater than180 mmHg or resting diastolic blood pressure greater than 100 mmHg),and untreated/undertreated hyperthyroidism; 8.Male or female with family planning concerns; 9.Involvement in other drugs or medical devices clinical research for a duration of approximately3 months.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 3D-CAM;NRS-R scores within 48h post-op and total rescue med dosage;Averse event;The quality of recovery on the third postoperative day;Intraoperative cerebral desaturation incidence rate; | — |
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality on the first day; | — |
Countries
China
Contacts
Public ContactLeng Zhou
West China Hospital of Sichuan University
Outcome results
None listed