Senile deafness
Conditions
Interventions
Case group (Elderly with hearing loss):NA
Control group (Elderly without hearing loss:NA
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Case groupInclusion criteria: 1. Age >=65 years; 2. Sign informed consent and participate in the study voluntarily; 3. Hearing loss is the main symptom, which can be accompanied by vertigo, tinnitus, hypertension, diabetes, and hyperlipidemia; 4. Able to cooperate with the completion of various listening tests and subsequent sample collection processes. Control group:Inclusion criteria: 1. Age >=65 years; 2. Sign informed consent and participate in the study voluntarily; 3. No hearing impairment related symptoms, no previous history of ear disease, no long-term exposure to strong noise environment work history; 4. Able to cooperate with the completion of various listening tests and subsequent sample collection processes.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the case group: 1. Patients with hearing impairment caused by other clear causes other than hearing loss, such as a history of ear trauma, ear surgery, Meniere's disease, sudden deafness; 2. Suffering from severe mental illness or cognitive impairment, unable to communicate normally, affecting the accuracy of research data collection; 3. It is inconvenient to collect additional blood samples due to anemia disease; 4. Patients with serious diseases such as advanced malignant tumors that seriously affect their survival expectations and are unable to participate in the full study; 5. Use of ototoxic drugs that may affect hearing within the last 3 months. Exclusion criteria for control group: 1. Family history of hereditary hearing loss; 2. Suffering from severe mental illness or cognitive impairment, unable to communicate normally, affecting the accuracy of research data collection; 3. It is inconvenient to collect additional blood samples due to anemia disease; 4. Patients with serious diseases such as advanced malignant tumors that seriously affect their survival expectations and are unable to participate in the full study; 5. Have a history of ear surgery, ear trauma or long-term use of drugs that may affect hearing within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Audiological evaluation;Transcriptomic analysis;proteomic analysis; | — |
Countries
China
Contacts
Public ContactAnchun Deng
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed