Preoperative anxiety, preoperative anxiety can lead to preoperative and intraoperative hypertension, rapid heart rate and other conditions, which can seriously affect surgical treatment
Conditions
Interventions
Control group:Saline spray
Experimental group:Dexmedetomidine hydrochloride nasal spray was administered
Sponsors
People's Hospital of Leshan
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >= 18 years who underwent elective surgery were of all genders; 2. The ASA score is I-III; 3. 18.5 kg/m2 <= BMI<28kg/m^2; 4. Preoperative screening of patients with anxiety; 5. Volunteer to participate in the study and sign an informed consent;
Exclusion criteria
Exclusion criteria: 1. History and risk of airway difficulties (e.g., subjects with obstructive sleep apnea syndrome); 2. The subjects had psychiatric disorders (such as schizophrenia, mania, insanity, etc.), subjects taking anti-anxiety drugs before surgery (such as benzodiazepines, melatonin, pregabalin, etc.), arrhythmias (sinus tachycardia, sinus bradycardia, ventricular premature beat, etc.), and cognitive disorders; 3. Subjects with a history of myocardial infarction or unstable angina pectoris, or a history of cardiac insufficiency within 6 months prior to the screening period; 4. Subjects with poor blood pressure control after medication (hypertension: systolic >= 180mmHg, or diastolic >= 110mmHg, or hypotension: systolic < 90mmHg or diastolic <= 50mmHg); 5. Allergic or contraindicated to dexmedetomidine hydrochloride and its drug components; 6. Subjects are not suitable for nasal administration (such as severe rhinitis, nasal deformity, etc.) or do not want to receive nasal administration; 7. Other conditions considered inappropriate for the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of first hypertension after entry and before anesthesia;Incidence of anxiety before anesthesia began in patients after entry; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of recovery scores at day 1, day 3, and day 30 (QoR-15);The incidence of preoperative anxiety in different surgical types;Postoperative pain score, incidence of anxiety, sleep score, nausea and vomiting, length of hospital stay, medical costs, and mortality; | — |
Countries
China
Contacts
Public ContactLiang Jin
People's Hospital of Leshan
Outcome results
None listed