Osteoarthritis and end-stage knee disease
Conditions
Interventions
Study Group:Patients who received LB will be categorized as the Group LB .:The four-in-one nerve blockade was performed using the convex array transducer combined with nerve stimulator at the mid-thi
Control Group :Patients who received ropivacaine will be categorized as the Group RP .:The four-in-one nerve blockade was performed using the convex array transducer combined with nerve stimulator a
Sponsors
Foshan Fosun Chancheng Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Agree to participate in this study and voluntarily sign the informed consent form; Patients undergoing elective unilateral TKA; Anesthesia: combined spinal-epidural anesthesia; Age 65~80 years old, gender is not limited; ASA Class II or III; BMI 18~27 kg/m^2; Postoperatively, ultrasound-guided peripheral nerve block analgesia was performed.
Exclusion criteria
Exclusion criteria: 1.Pregnant women,or individuals with neurological or neuromuscular diseases. 2.Individuals with severe cerebrovascular diseases,traumatic brain injury,cerebrovascular accident,epilepsy,stroke,severe cardiovascular diseases,uncontrolled hypertension,or a history of peptic ulcer disease. 3.Individuals with allergies to local anesthetics or opioids. 4.Individuals with communication disorders,or a history of psychological or psychiatric conditions. 5.Contraindications to regional anesthesia(e.g.,abnormal coagulation function,local infection). 6.Individuals with a history of alcohol or drug abuse,or preoperative use of opioids or sedative medications. 7.Individuals with a history of allergies to opioids,or allergies to the intraoperative medications or postoperative rescue analgesic medications specified in the protocol. 8.Individuals with acute or chronic pain(continuous for 3 months or intermittent for 6 months)unrelated to the surgical site.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean pain scores (RVAS and MVAS) between the group LB and RP at different points in the 72 hours;The total and mean opioid use of oxycodone used as a rescue medication at the first 24h, 24-48h, and 48-72h intervals and the total amount used in the first 72h postoperatively between the two groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle strength at different times in 72 hours after surgery which was evaluated using MRC with 5 grade;The incidence of postoperative adverse event.;Hospital lengths of stay (LOS);Satisfaction of patients; | — |
Countries
China
Contacts
Public ContactMeirong Wang
Foshan Fosun Chancheng Hospital
Outcome results
None listed