Pancreatic cancer
Conditions
Interventions
Covered Stent Implantation Combined with periarterial divestment Group:Covered stent implantation followed by arterial sheath dissection
Periarterial divestment Group:Arterial sheath dissection alone.
Sponsors
The Affiliated BenQ Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1)Preoperative imaging demonstrates involvement of the celiac axis (CA) and its branches — the splenic artery (SA), common hepatic artery (CHA), and left gastric artery (LGA) — with tumor encasement exceeding 180° of the vessel circumference;(2)No evidence of distant metastasis; (3)Undergoing curative-intent pancreatic cancer surgery; (4)Presence of a suitable arterial access route enabling interventional therapy targeting the celiac axis and/or superior mesenteric artery (SMA); (5)Ability to understand the purpose of the study, with voluntary consent to participate; informed consent form signed by the patient or their legally authorized representative, with willingness to adhere to study protocols and complete scheduled follow-ups; (6)Assessment by at least two interventional radiologists confirming the patient as high-risk for surgical intervention, or determination of existing surgical contraindications.
Exclusion criteria
Exclusion criteria: (1)Patients aged >85 years or 400×10?/L), or history of bleeding diathesis/coagulopathy;(11)Pregnancy or lactation;(12)Known allergy to contrast agents;(13)Estimated life expectancy of less than 12 months;(14)Participation in other investigational drug or device clinical trials;(15)Any other condition or abnormality deemed by the investigator to potentially interfere with endovascular intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of covered stent;Arterial rupture rate;Intraoperative blood loss;R0 resection rate of tumor;Postoperative bleeding rate;In hospital mortality;Length of stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;Gender;BMI;blood sugar;Preoperative biliary drainage volume;Pancreatic texture;Pancreatic duct diameter;Pathological classification;Postoperative complications;Hospitalization expenses;Length of hospital stay;Survival prognosis; | — |
Countries
China
Contacts
Public ContactYi Miao
Pancreas Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China
Outcome results
None listed