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Mechanism of remodeling of intestinal microbiota and inflammatory metabolism of Omega-3 PUFA combined with CBT intervention in adolescent depressed patients.

Mechanism of remodeling of intestinal microbiota and inflammatory metabolism of Omega-3 PUFA combined with CBT intervention in adolescent depressed patients.

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500102002
Enrollment
Unknown
Registered
2025-05-07
Start date
2025-05-26
Completion date
Unknown
Last updated
2025-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Control group:Patients receive regular medication in the hospital, and take one soybean oil placebo with the same appearance as Omega-3 (containing 50mg of vitamin E) every day.
Omega-3 Intervention Group:Patients will receive regular hospital medication. Meanwhile, they will be administered with one omega-3 supplement capsule daily for a continuous period of eight weeks. Eac
Omega-3 + Cognitive Behavioral Therapy (CBT) Combined Intervention Group:Patients will receive regular hospital medication. Meanwhile, they will take one omega-3 supplement capsule daily for eight con

Sponsors

ZhumadianSecond People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 18 Years

Inclusion criteria

Inclusion criteria: (1) Children's Depression Inventory (CDI) score greater than 19 points; (2) The age of adolescents at the time of assessment and treatment is 12 to 18 years old; (3) The subject's cognition and communication were normal; (4) the child has no history of developmental disabilities (e.g., autism); (5) The patient is the first patient.

Exclusion criteria

Exclusion criteria: (1) The subject has received psychotherapeutic intervention; (2) Suffering from major mental illnesses such as bipolar disorder, anxiety disorder, and schizophrenia at the same time; (3) Accompanied by serious major organ diseases or physical diseases; (4) Have serious suicidal behaviour; (5) The patient and guardian are unable to cooperate with the treatment process.

Design outcomes

Primary

MeasureTime frame
Children's Depression Inventory (CDI);The Temporal Experience of Pleasure Scale (TEPS);

Secondary

MeasureTime frame
Snaith–Hamilton pleasure scale (SHAPS);Childhood Trauma Questionnaire (CTQ);Semi - quantitative Food Frequency Questionnaire (FQQ);

Countries

China

Contacts

Public ContactHe Lei

ZhumadianSecond People's Hospital

embp10107777@gmail.com+86 139 3839 9234

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026