Major Depressive Disorder
Conditions
Interventions
Patients with Major Depressive Disorder:None
Healthy Control:None
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for patients with MDD were as follows: (1) aged 18 to 55 years, with a male to female ratio of 1:1; (2) rated as right-handed according to the Sharp Handedness Program Questionnaire; (3) met the Diagnostic and Statistical Manual, 5th edition (DSM-5) clinical diagnostic criteria for MDD; (4) first episode without antidepressant medication; (5) Hamilton Depression Scale 17-item (HAMD-17) score >= 17; (6) years of education >= 9 years, no verbal communication difficulties, and able to cooperate with the assessment and treatment; and (7) obtaining written informed consent from the patient. Enrollment criteria for healthy subjects were as follows: (1) aged 18 to 55 years, with a male-to-female ratio of 1:1; (2) assessed to be right-handed according to the Sharp Handedness Program Questionnaire; (3) >= 9 years of education; and (4) voluntarily signed a written consent form and were willing to cooperate with the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with MDD included (1) those who met the diagnostic criteria for schizophrenia, schizoaffective disorder, bipolar disorder, mental retardation, pervasive developmental disorder, delirium, dementia, memory disorders, or other cognitive disorders; (2) those who suffered from severe unstable somatic diseases, organic brain diseases (e.g., ischemic strokes, brain hemorrhages, and brain tumors) or a history of severe traumatic brain injury, narrow angle glaucoma; (3) a history of alcohol or substance abuse/dependence within the past 1 year; (4) a history of loss of consciousness for more than 5 minutes; (5) a history of suicide attempts, severe suicidal ideation (Self-rating Idea of Suicide Scale (SIOSS) >=12 points); (6) those who have received electroconvulsive ECT, rTMS treatment within the past 3 months (6) those who have received electroconvulsive ECT, rTMS treatment in the past 3 months; (7) pregnant or breastfeeding women, or those who are planning to be pregnant; (8) those who have pacemakers, cochlear implants, or other metallic foreign bodies and any electronic equipment implanted in the body, and those who have contraindications to magnetic resonance scanning, such as claustrophobia; and (9) those who are deemed unsuitable for participation by the investigator. Exclusion criteria for healthy subjects included (1) the person or a first-degree relative suffering from any mental disorder that met the diagnostic criteria through the MINI interview; (2) a serious unstable physical illness, organic brain disease (e.g., ischemic stroke, cerebral hemorrhage, brain tumor, etc.) or a history of severe traumatic brain injury, narrow-angle glaucoma; (3) a history of postalcoholic substance abuse/dependence in the past 1 year; (4) a history of loss of consciousness for more than 5 minutes; (5) history of suicide attempts, serious suicidal ideation or behavior; (6) pregnant or breastfeeding women, or those who are planning to become pregnant; (7) persons with pacemakers, cochlear implants, or other metallic foreign objects and any electronic equipment implanted in the body, and persons with contraindications to MRI scanning, such as claustrophobia; and (8) those who, in the opinion of the investigator, are unsuitable for the participant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-rating Idea of Suicide Scale;Ruminative Responses Scale;Stress Mindset Measure;Connor—Davidson resilience scale,CD—RISC;Beck Depression Inventory;THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction; | — |
Countries
China
Contacts
Public ContactWeihua Yue
Peking University Sixth Hospital
Outcome results
None listed