New-onset essential hypertension
Conditions
Interventions
Sham-operated control group:Sham-operated
Perirenal fat modification treatment group:Perirenal fat modification therapy with focused power ultrasound
Sponsors
Army Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-65 years; 2. In resting state: office systolic blood pressure 140-160mmHg, or (and) office diastolic blood pressure 90-100mmHg; 3. initial hypertension without antihypertensive medication; 4. The fat volume of the lower pole of unilateral kidney measured by ultrasound was > 8000mm^3 (the upper and lower diameters, left and right diameters and anterior and posterior diameters should all >=20mm); 5. All subjects voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. office SBP >=160 MMHG, or/and office DBP >=100 MMHG; 2. The presence of secondary hypertension [if secondary hypertension is suspected, the common secondary hypertension should be excluded, including renal hypertension (renal parenchymal lesions, renal artery stenosis), primary aldosteronism, Cushing syndrome, pheochromocytoma, aortic coarctation, severe obstructive sleep apnea]; Secondary hypertension; 3. acute myocardial infarction or malignant arrhythmia in the past 6 months; 4. recent stroke history (within 6 months); 5. dilated heart disease, hypertrophic cardiomyopathy, rheumatic heart disease, congenital heart disease, severe valvular heart disease (severe valvular stenosis or regurgitation); 6. patients with serious medical conditions, such as cancer; 7. severe liver or renal dysfunction (ALT and/or AST) >= 3 times the upper limit of normal, or end-stage renal disease on dialysis or eGFR 2.5mg/dL[> 221µmol/L]); 8. symptomatic heart failure or reduced left ventricular ejection fraction (< 40%) within the past 6 months; 9. bilateral renal skin diseases are not suitable for contact therapy; 10. participating in other clinical investigators; 11. During the study period, patients could not live in the local area of the study center for a long time, which was not conducive to follow-up; 12. pregnant, lactating, or preparing to become pregnant; 13. patients with poor adherence or other reasons considered by the investigator to be ineligible for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Office blood pressure and 24-hour ambulatory blood pressure changes at 6-month follow-up; | — |
Secondary
| Measure | Time frame |
|---|---|
| Office systolic blood pressure and diastolic blood pressure ;24-hour ambulatory blood pressure;Blood pressure compliance rate (clinic blood pressure<140/90mmHg); | — |
Countries
China
Contacts
Public ContactYang Xiaoli
Army Medical Center of PLA
Outcome results
None listed