Lung tumor
Conditions
Interventions
Remimazolam group:General anesthesia was induced with sevoflurane and remifentanil, and maintained with remifentanil. Remifentanil was continuously pumped at a rate of 0.5 mg·kg-1·hr-1 from 3 minutes
The dexmedetomidine group:General anesthesia was induced by sevoflurane, remifentanil and dexmedetomidine. Dexmedetomidine was continuously pumped at a rate of 0.5 ug ·kg-1·hr-1 from 3 minutes before
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Patients scheduled for elective unilateral thoracoscopic surgery; (2) Age >= 65 years; (3) ASA classification: I-III grade;
Exclusion criteria
Exclusion criteria: (1) BMI less than 18 kg/m^2 or BMI greater than 30 kg/m^2; (2) Patients with language comprehension disorders, mental illness and other conditions that prevent cooperation; (3) Ejection fraction of the heart less than 40%, heart rate less than 50/min, arrhythmias other than first-degree atrioventricular block; (4) Liver and kidney dysfunction; (5) Epilepsy and related mental and cognitive functional disorders, long-term stress stimulation or psychological disorders; (6) History of alcohol abuse, dependence on analgesic drugs and long-term use of sedatives; (7) Allergic to the study drug; (8) Those who do not sign the informed consent form. ;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium;Postoperative agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative QoR-15 Quality of Recovery Score;Postoperative NRS pain score;Postoperative sleep scale score;The incidence of intraoperative hypotension and heart rate < 50;The time from the end of the surgery to extubation, and the duration of stay in the PACU;Time of removal of thoracic drainage tube, Postoperative hospital stay duration; | — |
Countries
China
Contacts
Public ContactYan Ming
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed