Sick Sinus Syndrome
Conditions
Interventions
BBP Group:Bachmann Bundle Pacing
RAAP Group:Right Atrial Appendage Pacing
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Diagnosis of sick sinus syndrome (SSS); 3. Presence of any of the following conditions with a plan for first-time pacemaker implantation: (1). Symptomatic bradycardia (e.g., syncope, dizziness, fatigue) with symptoms attributable to bradycardia; (2). Bradycardia-tachycardia syndrome: characterized by predominant bradycardia with episodes of atrial tachyarrhythmias; (3). Exercise-induced symptoms, particularly in participants with chronotropic incompetence (i.e., inability to appropriately increase heart rate during exercise); (4). Asymptomatic participants with documented sinus arrest > 6 seconds; 4. Willingness to participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Persistent atrial fibrillation/atrial flutter lasting more than 7 days, or permanent atrial fibrillation/atrial flutter; 2. Arrhythmias other than paroxysmal atrial fibrillation (lasting less than 7 days) and sick sinus syndrome; 3. Use of antiarrhythmic drugs before pacemaker implantation; 4. New York Heart Association (NYHA) functional class III or IV; 5. Congenital heart disease; 6. Severe valvular regurgitation, including severe tricuspid regurgitation, mitral regurgitation, pulmonary valve regurgitation, or aortic regurgitation; 7. Cardiomyopathy; 8. Cardiac surgeries involving cardiopulmonary bypass that remove the atrial appendage or affect atrial structure, including coronary artery bypass grafting, valve surgery, surgery for congenital heart disease, cardiac tumor surgery, heart transplantation, etc.; 9. History of atrioventricular node ablation; 10. Severe renal disease or other systemic diseases; 11. Within three months after angina or acute myocardial infarction; 12. Other conditions deemed inappropriate for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atrial fibrillation episodes (duration >=6 minutes); | — |
Secondary
| Measure | Time frame |
|---|---|
| Atrial fibrillation episodes (duration >=6 hours);Atrial fibrillation episodes (duration >=24 hours);Atrial fibrillation burden;Incidence of cerebral embolism;All-cause mortality;Cardiovascular mortality;Health-related quality of life; | — |
Countries
China
Contacts
Public ContactYongquan Wu
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed