Postoperative delirium
Conditions
Interventions
Experimental group:Infusion of crystalloid solution at 12 ml/kg within 1 hour prior to anesthesia induction
Control group :Infusion of crystalloid solution at 2.5 ml/kg within 1 hour prior to anesthesia induction.
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1 Patients aged 65 years and older, of any gender; 2 Patients with ASA classification of I-III; 3 Patients scheduled for elective non-cardiac and non-neurosurgical procedures; 4 Patients with no communication barriers and able to comply with all protocols during the trial.
Exclusion criteria
Exclusion criteria: 1 History of neurological diseases, dementia, or other psychiatric disorders; 2 Preoperative MMSE score less than 20; 3 History of severe auditory, visual, or motor impairments; 4 Patients with preoperative delirium; 5 Hematocrit (Hct) < 30% or hemoglobin (Hb) < 10 g/L; 6 History of allergy to hydroxyethyl starch or gelatin; 7 Significant heart, liver, or kidney dysfunction, or coagulation abnormalities; 8 Illiteracy or communication barriers; 9 Recent participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| the severity of postoperative delirium;the types of postoperative delirium ;the duration of postoperative delirium;sleep quality assessment;postoperative pain score;cognitive function assessment;physical function assessment;frailty assessment;incidence of postoperative nausea and vomiting;postoperative recovery quality score;length of hospital stay;30-day mortality rate;Mini-Mental State Examination;Short IQ Test;postoperative adverse events record;intraoperative adverse events record; | — |
Countries
China
Contacts
Public ContactYingwei Wang
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed