Rotator cuff injury
Conditions
Interventions
Test Group 1:In the S1 group, 0.5 mg/kg esketamine was intravenously administered in 5 ml dilution before skin incision. During surgery, continuous infusion at 0.25 mg/kg/h was maintained until skin c
Control group (Group C):In Group C, a 5ml normal saline IV injection was given before skin incision. Continuous IV infusion at the esketamine group's dosage was maintained until skin closure.
Test Group 2:In the S2 group, 0.25 mg/kg esketamine was intravenously administered in 5 ml dilution before skin incision. During surgery, continuous infusion at 0.125 mg/kg/h was maintained until skin
Sponsors
West China Hospital, Sichuan university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: 18-65 years old, regardless of gender 2: ASA I-II grade 3: 18.5 kg/m^2<= BMI <28kg/m^2 4: Arthroscopic rotator cuff repair under general anesthesia 5: Individuals who volunteer to participate in this study must possess proficient reading and writing skills and be capable of signing the informed consent form
Exclusion criteria
Exclusion criteria: 1: Patient with severe heart, brain, liver and kidney diseases; 2: Patient with long-term history of taking psychotropic drugs and diagnosed mental illness; 3: Inability to communicate before surgery due to cognitive impairment or language impairment; 4: Long-term use of psychiatric medications and diagnosed mental disorders. 5: Drug or alcohol abuse in the past 3 months, averaging >2 units daily (1 unit = 360ml 5% beer, 45ml 40% liquor, or 150ml wine); 6: It is planned to enter ICU after operation; 7: Known allergic to esketamine; 8: Patient contraindicated for esketamine injection: intracranial aneurysm, elevated blood/intracranial pressure risk, high intraocular pressure/glaucoma/penetrating eye injury, uncontrolled hypertension (resting BP >180/110 mmHg), or untreated hyperthyroidism; 9: Men and women planning to have children; 10: Participation in other clinical trials within the past three months; 11: Researchers found more reasons to exclude participants from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of NRS-R score >= 4 within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| delirium;;Ramsay;adverse event;Total rescue medication given within 48 hours post-surgery;Patient and family satisfaction with postoperative pain management; | — |
Countries
China
Contacts
Public ContactLeng Zhou
Department of Anesthesiology, West China Hospital, Sichuan university
Outcome results
None listed