postoperative pain on thoracoscopic lung surgery
Conditions
Interventions
C group:sufentanil 1.5µg/ml
E3 group:SHR8554 0.125mg/kg
E1 group:SHR8554 0.075mg/kg
E2 group:SHR8554 0.1mg/kg
Sponsors
The First People’s Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 18~85 years old (including the cut-off value), gender is not limited; 2. Body mass index (BMI): 18.0~30.0kg/m^2 (including cut-off value); 3. The American Society of Anesthesiologists (ASA) grades are rated I to III preoperatively; 4. Elective thoracoscopic lung surgery under general anesthesia; 5. Able to understand the purpose, process and scale scoring method of this trial, the subject can operate the PCIA equipment, and can communicate effectively with the investigator; 6. Subjects voluntarily participate in this trial and sign written informed consent;
Exclusion criteria
Exclusion criteria: 1. Those who know or suspect allergies or contraindications to the components of the investigational drug or other opioids or other drugs specified in the course of the trial; 2. Patients with severe cardiovascular disease, liver and kidney insufficiency, neuropsychiatric dysfunction, and those who cannot cooperate with pain assessment; 3. Those with a history of long-term chronic pain; 4. Patients with severe respiratory and circulatory failure during anesthesia surgery; 5. Voluntary withdrawal from this trial;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in total pain intensity within 0~48h (SPID48); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting at 48 hours;Comparison of patients' global impression scores 48 hours after the first dose of study drug;Proportion of subjects using salvage medications;The number and dose of salvage medications used;Proportion of subjects with treatment failure due to inadequate analgesic efficacy;Time to first use of salvage medication;The total number of compressions and the number of effective compressions and the total compression dose of the PCIA pump during the 48-hour period; | — |
Countries
China
Contacts
Public ContactXiaobao zhang
The First People’s Hospital of Lianyungang
Outcome results
None listed