ARDS patients undergoing prone ventilation with tissue hypoperfusion
Conditions
Interventions
Gold Standard:A fluid challenge was performed by rapid administration of 4 mL/kg normal saline via a central venous catheter over 10 minutes. Fluid responsiveness was defined as a >=15% increase in st
Index test:Cumulative absolute percentage changes in SVI following EEO and EIO maneuvers
Sponsors
Tianjin Third Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. Patients with ARDS undergoing prone ventilation; 3. Currently monitored with a PiCCO device for hemodynamic parameters; 4. Presence of at least one of the following criteria indicating tissue hypoperfusion: 5. Systolic blood pressure 50 mmHg from baseline in hypertensive patients); Requirement for vasoactive agents (*dopamine >5 µg/kg/min or norepinephrine administration*); 6. Arterial lactate level >2 mmol/L; 7. Urine output 100 beats per minute); 9. Prolonged capillary refill time (>3 seconds) or mottled skin.
Exclusion criteria
Exclusion criteria: 1. Contraindications to fluid challenge (e.g., acute coronary syndrome, heart failure, cardiogenic shock, or evidence of volume overload); 2. Inability to tolerate 15-second end-inspiratory occlusion (EIO) and 15-second end-expiratory occlusion (EEO) maneuvers; 3. Arrhythmias.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke volume index, SVI;Receiver Operating Characteristic (ROC) curve;AUC; | — |
Countries
China
Contacts
Public ContactZhiyong Wang
Tianjin Third Central Hospital
Outcome results
None listed