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Effect and mechanism analysis of Haikun Shenxi Capsule combined with SGLt-2 inhibitor on ESRD

Effect and mechanism analysis of Haikun Shenxi Capsule combined with SGLt-2 inhibitor on ESRD

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101924
Enrollment
Unknown
Registered
2025-05-06
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End-Stage Renal Disease

Interventions

Control Group:Received Haikun Shenxi Capsules
Treatment group:Received Compound Danshen Injection
Combined group:The combination group was treated with Hekun Nephroprotective Capsules in combination with an SGLT-2 inhibitor, specifically Canagliflozin tablets, similar to the treatment group.

Sponsors

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Meet the diagnostic criteria for ESRD; 2.Have signed informed consent forms; 3.Possess good cognitive function and the ability to communicate effectively.

Exclusion criteria

Exclusion criteria: 1.Individuals with mental disorders; 2.Those accompanied by severe organic lesions ; 3.Individuals with primary or spontaneous autoimmune disorders; 4.Those with congenital heart disease; 5.Those accompanied by severe infectious diseases.

Design outcomes

Primary

MeasureTime frame
Blood Urea Nitrogen;Serum Creatinine;Endogenous Creatinine Clearance;24-hour Urine Protein Excretion;Plasma fibronectin;serum hyaluronic acid;Serum laminin ;Plasma type III procollagen;High-sensitivity C-reactive protein ;Tumor necrosis factor-alpha ;Vascular cell adhesion molecule -1;Monocyte chemotactic protein-1 ;Proteinuria;

Countries

China

Contacts

Public ContactShaohua Cui

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology

122792284@qq.com+86 186 8610 7952

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026