primary Sjögren's syndrome
Conditions
Interventions
Gold Standard:Classifcation criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group
Index test:Spectral CT multimodal imaging
Sponsors
Tongji University Affiliated Tongji Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-75 years old 2. Patients with dry mouth symptoms 3. Women of childbearing age who have had a negative urine pregnancy test and who are not currently planning to become pregnant. 4. Not using hormones or immunosuppressants 5. Able to read, understand and give written informed consent
Exclusion criteria
Exclusion criteria: 1. History of cervicofacial radiotherapy 2. Hepatitis C virus infection 3.AIDS 4. History of lymphoma 5. History of sarcoidosis 6. Combined with other rheumatic immune diseases (including but not limited to rheumatoid arthritis, systemic lupus erythematosus, inflammatory myopathy, systemic sclerosis, primary biliary cirrhosis, etc.) 7. For patients with serious heart, liver, kidney and other important organ lesions, the evaluation criteria are as follows: A: Heart disease: patients with decompensated cardiac insufficiency or refractory hypertension (hypertension that cannot control systolic and diastolic blood pressure at the target level despite lifestyle modification and use of diuretics, including adequate doses, reasonable combinations, and at least three antihypertensive drugs); Electrocardiogram (ECG) abnormality at screening that, in the opinion of the investigator, is clinically significant and may pose an unacceptable risk to the patient's enrollment in this study; b: Liver function: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) > = 2 times the upper limit of normal reference value (ULN); c: Renal function: combined with tubular and/or renal interstitial lesions, or renal insufficiency: serum creatinine=ULN or glomerular filtration rate (eGFR) <60ml/min/1.73m2; d: Other serious diseases: serious infections and tumors, etc.; 8. Pregnant and lactating females, or those of childbearing age who cannot guarantee effective contraception; 9. Those who are mentally ill or unable to cooperate with treatment for other reasons; 10. People with coagulation disorders 11. History of contrast agent allergy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CT values at different Kevs;Kev slope;Effective Atomic Number; | — |
Countries
China
Contacts
Public ContactYanqing Wang
Tongji University Affiliated Tongji Hospital
Outcome results
None listed