Chronic Endometritis
Conditions
Interventions
Antibiotic Treatment:Daily oral antibiotics for 2 weeks
Antibiotic Treatment + Probiotics Group:Daily oral antibiotics for 2 weeks, followed by direct consumption or oral intake of probiotics with room-temperature water, 1 sachet/day, for a total of 4 week
Sponsors
Guangdong Women and Children Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 42 Years
Inclusion criteria
Inclusion criteria: (1) Age range: 20-42 years old; (2) AMH > 1.1 ng/ml, menstrual cycle 25-37 days, relatively regular; (3) Diagnosis of chronic endometritis: typical hysteroscopic findings of chronic endometritis or pathological CD138 >= 5 cells/HPF; (4) Agree to participate in the study and sign the informed consent form: understand the study procedures and voluntarily participate.
Exclusion criteria
Exclusion criteria: (1) Recent antibiotic treatment: patients who have received antibiotic treatment within the past month, as it may affect the efficacy of probiotics. (2) Recent use of probiotics: patients who have used probiotics within the past two months, to exclude interference from other probiotics. (3) Severe gynecological inflammation or other reproductive system diseases: such as acute pelvic inflammatory disease, severe untreated hydrosalpinx, etc., which may interfere with study results. (4) Significant liver or kidney dysfunction: as hepatic or renal insufficiency may affect the metabolism of drugs and probiotics. (5) Allergy to probiotics or other drugs used in the study. (6) Exclusion of recurrent miscarriage or repeated implantation failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy Rate After the First Embryo Transfer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cure Rate of Chronic Endometritis;Differences in the composition of microbial communities in different parts of the reproductive tract in CE patients.;The impact of different treatment methods on the composition of the reproductive tract microbiota.;The correlation between the impact of different treatment modalities on the reproductive tract microbiota and clinical outcomes.;Identify microbial biomarkers significantly associated with CE (Chronic Endometritis).;To reveal how different treatment modalities regulate endometritis through microbe-host interactions using multi-omics integrated analysis.;The impact of different treatment methods on the diversity of the reproductive tract microbiota.;The impact of different treatment methods on the abundance of the reproductive tract microbiota.;Differences in the functionality of microbial communities in different parts of the reproductive tract in CE patients.; | — |
Countries
China
Contacts
Public ContactFenghua Liu
Reproductive medicine center of Guangdong Women and Children Hospital
Outcome results
None listed