Breast cancer
Conditions
Interventions
Group C (control group) : intravenous injection with 0.9% normal saline:Thirty minutes before the end of the operation, the same amount of 0.9% normal saline was intravenously injected.
Group D1: intravenous injection with dexmedetomidine at a dose of 0.2µg/kg:Thirty minutes before the end of the operation, dexmedetomidine at a dose of 0.2µg/kg was intravenously injected.
Group D1: intravenous injection with dexmedetomidine at a dose of 0.5µg/kg:Thirty minutes before the end of the operation, dexmedetomidine at a dose of 0.5µg/kg was intravenously injected.
Group D1: intravenous injection with dexmedetomidine at a dose of 0.8µg/kg:Thirty minutes before the end of the operation, dexmedetomidine at a dose of 0.8µg/kg was intravenously injected.
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Patients who have undergone radical mastectomy for breast cancer and general anesthesia with endotracheal intubation; 2. ASA Grade I - III; 3. Age >=60 years old; 4. No serious heart, lung or systemic diseases.
Exclusion criteria
Exclusion criteria: 1.Confirmed dementia, Parkinson's disease and stroke; 2. Age over 90; 3. Communication disorders or preoperative cognitive dysfunction; 4. Severe liver and kidney dysfunction; 5. Severe coagulation dysfunction; 6. Sick sinus node syndrome, severe sinus bradycardia or second-degree and above atrioventricular block without pacemaker; 7. Take sedatives and antidepressants; 8. History of alcohol or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative deliriuc; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of serum inflammatory factors and nerve injury markers; | — |
Countries
China
Contacts
Public ContactLi Qiang
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed