OCD
Conditions
Interventions
OCD experimental group:Transcranial alternating current stimulation
OCD control group:Sham tACS
Individualized theta?frequency tACS group:Individualized theta?frequency transcranial alternating current stimulation
Fixed theta?frequency stimulation group:Fixed 5?Hz stimulation frequency
Sham stimulation group:Sham tACS
Sponsors
The Second Affiliated Hospital of Xinxiang Medical College
Eligibility
Sex/Gender
All
Age
14 Years to 60 Years
Inclusion criteria
Inclusion criteria: Healthy Control Inclusion Criteria: a) Male or female, aged 18–30 years, currently enrolled as undergraduate or graduate students; b) Normal or corrected-to-normal vision, right-handed; c) No history of psychiatric or neurological disorders; d) No history of hypertension, diabetes, heart disease, cerebrovascular disease, malignant tumors, or other serious medical conditions; e) No history of traumatic brain injury or neurosurgery; f) No history of substance abuse or alcohol dependence; g) No use of sedative, hypnotic, analgesic, or related medications within 2 months prior to enrollment. OCD Group Inclusion Criteria: 1. Meets DSM-IV diagnostic criteria for obsessive–compulsive disorder; 2. Yale–Brown Obsessive–Compulsive Scale (Y-BOCS) total score = 16; 3. Aged 17–50 years, any gender; 4. Understands the study purpose and the safety profile of tACS and is willing to comply with treatment and assessments; 5. Has not received any non-pharmacological treatments (e.g., psychotherapy, rTMS, electroconvulsive therapy, tACS, etc.); 6. Has not taken any psychotropic medications for OCD, or if medicated, shows no significant symptom improvement in the 4 weeks prior to enrollment; 7. Normal or corrected-to-normal vision, right-handed.
Exclusion criteria
Exclusion criteria: 1 Presence of comorbid psychiatric disorders; 2 Diagnosed with hypertension, diabetes, heart disease, cerebrovascular disease, brain tumors, or other serious medical conditions; 3 History of substance abuse, alcohol abuse, or drug addiction; 4 History of traumatic brain injury, neurosurgery, or epilepsy; 5 Presence of severe physical illnesses; 6 Patient or family member refuses to undergo tACS treatment; 7 Presence of metallic implants or foreign bodies, such as metal braces, cardiac pacemakers, cochlear implants, or other contraindications for MRI scanning; 8 Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rs-EEG (resting-state Electroencephalogram);Functional magnetic resonance imaging, fMRI;Yale-brown compulsion scale, Y-BOCS;Hamilton depression scale, HAMD;Hamilton anxiety scale, HAMA;Baker Depression Self-rating Scale, BDI;Baker self-rating Anxiety Scale, BAI;Pittsburgh Sleep Quality Index, PSQI;Brief psychiatric inventory, BPRS;Event-related potential analysis, ERP (Event Related Potentials) ; | — |
Countries
China
Contacts
Public ContactZongya Zhao
The Second Affiliated Hospital of Xinxiang Medical College; School of Medical Engineering, Xinxiang Medical University
Outcome results
None listed