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Different Radiotherapy and Immunotherapy Combinations for Inducing Abscopal Effects in Multimetastatic Non-Small Cell Lung Cancer: A Prospective, Multicenter, Umbrella-Design Clinical Study

Different Radiotherapy and Immunotherapy Combinations for Inducing Abscopal Effects in Multimetastatic Non-Small Cell Lung Cancer: A Prospective, Multicenter, Umbrella-Design Clinical Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500101895
Enrollment
Unknown
Registered
2025-04-30
Start date
2025-05-01
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

Lymph node lesions + organ lesions + other lesions:Radiation therapy
Lung lesions + organ lesions + bone metastasis lesions:Radiation therapy
Lymph node lesions + visceral organ lesions + other lesions:Radiation therapy
Lung lesions + Lymph node lesions + visceral organ lesions:Radiation therapy
Lung lesions + visceral organ lesions+other lesions:Radiation therapy
Lung lesions + Lymph node lesions+bone lesions:Radiation therapy
Lung lesions + Lymph node lesions+other lesions:Radiation therapy

Sponsors

The Second Affiliated Hospital of the Army Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Non-small cell lung cancer (NSCLC) initially diagnosed by pathological histology; 2.with 3-6 metastases; 3.no brain metastasis or stable brain lesions; 4.negative for driver genes (including EGFR, ALK, ROS1, BRAF, MET, RET genes); 5.Eastern Cooperative Oncology Group (ECOG) performance status score: 0-1, with an expected survival of more than 3 months; 6.age between 18-75 years; 7.PET-CT assessment (including FDG and FMISO, not mandatory); 8.no contraindications for immunotherapy and radiotherapy; 9.signed informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with severe dysfunction of vital organs (heart, liver, kidneys); 2.those with other malignant tumors; 3.uncontrolled heart disease or myocardial infarction within the last 6 months; 4.history of mental illness; 5.other conditions deemed unsuitable for participation in the study by the investigator.

Design outcomes

Primary

MeasureTime frame
Abscopal response rate;

Secondary

MeasureTime frame
Overall Survival;Duration of Response;Immunotherapy-related adverse reactions;Progression-Free Survival (PFS);Objective Response Rate;

Countries

China

Contacts

Public Contactsunjianguo

The Second Affiliated Hospital of the Army Medical University

sunjg09@aliyun.com+86 23 68774490

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026