Autoimmune Gastritis
Conditions
Interventions
Conventional treatment group:Mecobalamin tablets 0.5mg, tid
Folic acid 5mg, qd
Conventional treatment combined with teprenone treatment group:Mecobalamin tablets 0.5mg, tid
Teprenone capsules 50mg/time, tid, with meal
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male or female, aged 18-70 years old; 2. Symptoms such as bloating and anorexia; 3. Positive gastroscopy and pathological results and/or serum antibody markers within 3 months prior to enrollment, and the results meet the diagnostic criteria for AIG proposed by the Japanese Society of Gastrointestinal Endoscopy: (1) Severe atrophy of the mucosa from the gastric body to the fundus by endoscopic examination and/or histopathological examination; (2) Positive gastric autoantibodies—positive anti-parietal cell (APCA) and/or anti-intrinsic factor (IFA) antibodies. Those who included (1) and (2) met at the same time; 4. The patient voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Untreated patients with active Helicobacter pylori infection; 2. Pathological examination with intraepithelial neoplasia; 3. Accompanied by other gastric mucosal lesions [such as active ulcer, active bleeding, gastric cancer, etc.]; 4. After gastrectomy; 5. Endoscopic treatment for intraepithelial neoplasia and adenoma in the past three months, such as ESD (endoscopic mucosal dissection) and EMR (endoscopic mucosal resection); 6. Those with obvious mental and behavioral abnormalities and emotional disorders; 7. Severe cardiovascular and cerebrovascular diseases, abnormal liver and kidney function; 8. Other malignant tumors are currently under treatment (chemotherapy, radiotherapy, immunotherapy, etc.); 9. Pregnant or lactating women; 10. Allergy to the study drug; 11. Patient has not signed the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Symptom Score;Compliance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum index detection; | — |
Countries
China
Contacts
Public ContactLi Jingnan
Peking Union Medical College Hospital
Outcome results
None listed