Postoperative analgesia
Conditions
Interventions
Experimental group:According to the data provided in the product manual of Tygilidine Fumarate Injection, the postoperative analgesic administration method of Tygilidine Fumarate was a loading dose of
Control group:The loading dose of sufentanil group was 3ug, the .9% normal saline configuration was 1ug/ml and 3 mg glastron, the background dose was 1ml/h, the single compression dose was 1ml, and th
Sponsors
Sichuan Provincial Maternal and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who are scheduled for gynecological transumbilical single-port laparoscopic surgery under general anesthesia and will undergo postoperative PCIA. 2. Age > 18 years. 3. Body mass index (BMI) 18.5–30kg/m^2. 4. ASA LEVELS I–III. 5. Voluntarily participate and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiocerebropathy, liver and kidney diseases; 2. Those who suffer from psychiatric diseases (schizophrenia, mania, bipolar abnormalities, mental confusion, etc.) and a history of long-term use of psychotropic drugs, have cognitive dysfunction, and are unable to communicate normally; 3. Those who are allergic to or contraindicated to benzodiazepines, opioids, propofol, muscle relaxants and other drugs and their drug components; 4. Those who plan not to remove the endotracheal tube after surgery. 5. Participated in drug clinical trials as a subject in the past 3 months; 6. Pregnancy or lactation 7. Other conditions that the investigator considers inappropriate to participate in this trial. 8. History of opioid use within eight weeks of surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting VAS score at 3h, 24h, and 48h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue medication situation in the operating room;Time to extubation after surgery;PCA self-controlled analgesia, actual number of compressions and effective number of compressions;Residual drug in postoperative PCIA;Visual analogue score (VAS score) at 3 h, 24 h, and 48 h postoperatively;FAS assessment scale score;QoR-15 Recovery Quality Score;Level of sedation (Ramsay Sedation Scoring Criteria);Side effects (nausea, vomiting, dizziness, itching, respiratory depression, etc.) and intestinal recovery time;First eating and first exercise;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactChen Benzhen/Cui Chang
Sichuan Provincial Maternal and Child Health Hospital
Outcome results
None listed