Infection with multi-drug resistant bacteria
Conditions
Interventions
Bacteriophage treatment group:Phage therapy
Sponsors
The Second Affiliated Hospital of Hainan Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with multi-drug resistant bacterial infections; 2. The pathogenic bacteria causing the infection of the patients should meet one of the following conditions: 1) The pathogenic bacteria are fully resistant to antibiotics; 2) They are resistant to key antibiotics; 3) The pathogenic bacteria are sensitive to key antibiotics in vitro but the treatment with such antibiotics is ineffective or has no obvious effect; 4) The use of key sensitive antibiotics for the pathogenic bacteria is restricted; 3. At least one lytic bacteriophage can be screened out; 4. The administration can be carried out through spraying on the infection site, external application, nebulization inhalation, perfusion, local injection or administration through drainage tubes; 5. The subjects and their families (or guardians) have fully read, understood and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Bacterial infections can be effectively controlled by antibiotics; 2. There is no other route of administration except intravenous injection; 3. Patients who, as determined by the researchers, are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Significantly inhibit, reduce or eliminate pathogenic bacteria; | — |
Countries
China
Contacts
Public ContactYi Wang
The Second Affiliated Hospital of Hainan Medical University
Outcome results
None listed