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The mechanism of CCR1 receptor regulating macrophage M1 polarization in interstitial cystitis

The mechanism of CCR1 receptor regulating macrophage M1 polarization in interstitial cystitis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500101878
Enrollment
Unknown
Registered
2025-04-30
Start date
2024-08-01
Completion date
Unknown
Last updated
2025-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Interstitial cystitis

Interventions

Interstitial cystitis:none
Non muscle invasive bladder cancer:none

Sponsors

Third Affiliated Hospital of Sun Yat sen University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Interstitial cystitis (1) Patients aged 18 and above; (2) Previously diagnosed as interstitial cystitis with a duration of>6 months; (3) Cystoscopy examination to determine the characteristic pathological manifestations of the bladder wall; (4) O'Leary Sant interstitial cystitis symptom and problem index score exceeding 18; (5) Those who agree to participate in this clinical study and sign the informed consent form. Non muscle invasive bladder cancer (1) Under cystoscopy, it appears as a single pedunculated tumor; (2) It meets the diagnostic criteria of non muscle invasive bladder cancer and is confirmed by pathology; (3) First diagnosis;

Exclusion criteria

Exclusion criteria: Interstitial cystitis (1) History of bladder diseases (overactive bladder, neurogenic bladder, bladder stones, radiation cystitis); (2) History of urethral diseases (urethral diverticulum, urethral stricture, urethral stones); (3) History of the following treatments within 24 weeks: bloating, bladder laser therapy, bladder electrocoagulation, transurethral resection and pelvic reconstruction surgery, nerve block or spinal cord stimulation to relieve pain; (4) History of bladder enlargement surgery or bladder resection surgery in the past; (5) Serious cardiovascular and cerebrovascular diseases, mental disorders, or clinical evaluations are not suitable for inclusion in the study. Non muscle invasive bladder cancer (1) Previous history of radiation and chemotherapy; (2) There are urinary system infections and stones present; (3) Important organ dysfunction; (4) Individuals who have undergone invasive urinary system examinations or surgeries within the past 3 months; (5) Merge with other malignant tumors; (6) Accompanied by mental disorders and cognitive impairments; (7) Metastatic bladder cancer

Design outcomes

Primary

MeasureTime frame
CCR1;

Secondary

MeasureTime frame
CCL2;CCL3;CCL4;CCL5;

Countries

China

Contacts

Public ContactXiangfu Zhou

Lingnan Campus of the Third Affiliated Hospital of Sun Yat sen University, Guangzhou, Guangdong Province

liwenshuang2020@163.com+86 156 2215 0803

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026