Acute hypoxic respiratory failure
Conditions
Interventions
Control group:Receiving nasal high-flow oxygen therapy (HFNO)
Experimental group:Oxygen is given with a nasal mask for anesthesia
Sponsors
Gansu Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age>=18 years; 2) respiratory rate > 25 breaths/min, or accompanied by acute onset (<1 week) respiratory distress; 3) PaO2/FiO2 < 300 mmHg or pulse oximetry (SpO2) <90% when inhaled air; 4) Patients voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Acute exacerbation of severe asthma (involving respiratory muscles) or chronic obstructive pulmonary disease; 2) history of chronic respiratory failure or moderate to severe cardiac insufficiency (New York cardiac function class greater than grade 2 or left ventricular ejection fraction less than 45%); 3) clinical evidence of cardiogenic pulmonary edema; Hemodynamic instability (systolic blood pressure 45mmHg); 5) Glasgow Coma Score <13; 6) Facial anatomy contraindications to nasal mask or nasal cannula application; 7) Pregnant or lactating patients; 8) the need for invasive mechanical ventilation (IMV) prior to the start of the study; 9) The patient is unable to cooperate with treatment or observation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygen therapy method shift rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Partial pressure of oxygen (PaO2) Heart rate (HR), oxygen saturation (SpO2), partial pressure of carbon dioxide (PaCO2);Total length of stay;Intubation rate;Dyspnea score;Adverse events;Patient Satisfaction;Time from 28 days after enrollment to clinical recovery; | — |
Countries
China
Contacts
Public ContactWenjun Yan
Gansu Provincial Hospital
Outcome results
None listed