Calculous cholecystitis
Conditions
Interventions
Experimental group:Anesthesia induction: intravenous injection of 0.4 µ g/kg of sufentanil citrate injection, 0.3 mg/kg of cyclosporine, and 0.15 mg/kg of cisplatin.
Anesthesia maintenance: Continuous
Control group:Anesthesia induction: intravenous injection of 0.4 µ g/kg sufentanil citrate injection, 1.5 mg/kg propofol, and 0.15 mg/kg cisplatin. Anesthesia maintenance: Continuous infusion of propo
Sponsors
Guangyuan first people's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. ASA Grading I.-III; 2. Gender is not limited, age >=65 years old and =18 and <=30kg/m^2; 4. The estimated operation time is 1~3 hours; 5. Able to understand the procedures and methods of this study, willing to sign informed consent and strictly abide by this trial protocol to complete this study.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to general anesthesia or those who have had a history of anesthesia accidents in the past; 2. Those who are known to be allergic to the excipients in propofol injection, cyclopofol injection excipients (soybean oil, glycerol, triglycerides, egg yolk lecithin, sodium oleate and sodium hydroxide), benzodiazepines, opioids, cis-atracurium and its drug components; Those with contraindications to propofol; 3. Serious diseases such as liver and kidney dysfunction, blood system diseases, immune system diseases, etc.; 4. Subjects who, in the opinion of the investigator, have any other factors that are not suitable for participating in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative incidence of PND; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wake-up time;Steward Awakening Rating;Mean arterial pressure;Heart rate;Injection pain;postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactYang Chuan
Guangyuan first people's Hospital
Outcome results
None listed