None
Conditions
Interventions
Normal saline group:The right stellate ganglion block is not performed before the operation. During the operation, an equal volume of 0.9% sodium chloride is infused until the end of the operation
Esketamine group:The right stellate ganglion block is not performed before the operation. During the operation, esketamine is continuously pumped at a dose of 0.3mg/kg/h until the end of the operation
Esketamine + Stellate ganglion block group:Before induction, the right stellate ganglion block is performed. During the operation, esketamine is continuously pumped at a dose of 0.3mg/kg/h until the e
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-75 years; 2. Body Mass Index (BMI): 18-29.5 kg/m^2; 3. ASA: I - III; 4. Patients undergoing elective gynecological laparoscopic surgery.
Exclusion criteria
Exclusion criteria: 1. Pre-existing sleep disorders with a Pittsburgh Sleep Quality Index (PSQI) score greater than 5; 2. Severe hypertension, diabetes, and cerebrovascular diseases; 3. Long-term use of sedatives or antidepressants; 4. History of motion sickness, smoking, and alcohol dependence; 5. Previous neurological, psychiatric, or psychological conditions that prevent cooperation or understanding of the scale content; 6. Recent history of drug abuse; 7. Refusal to participate; 8. Allergy to or contraindications for the trial medication; 9. Contraindications for regional anesthesia: abnormal clotting function, infection at the puncture site, allergy to local anesthetics, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of sleep disorders 48 hours after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety and Depression Index;Postoperative sleep structure;Pittsburgh sleep quality index(PSQI)score;Postoperative VAS scores;Quality of recovery-15 (QoR-15) score;Postoperative nausea and vomiting rate;Postoperative gastrointestinal function;Time to first flatus;The number of flatulence within 48 hours after the operation;The usage of perioperative analgesic drugs; Hemodynamic parameters (systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate);The usage of vasoactive drugs;Postoperative estimated incidence rate;The satisfaction of patients;Length of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactMengxing Jia
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed