Pulmonary disease
Conditions
Interventions
Control Group (Group C):Routine intravenous anesthetic maintenance during surgery, without esketamine.
Normal saline was continuously infused at an equivalent rate until skin closure.
Low-Dose Esketamine Group (Group ES1):In addition to the maintenance of conventional intravenous anesthetics, esketamine 0.125 mg·kg^-1·min^-1 was continuously infused intravenously to the suture.
Medium-Dose Esketamine Group (Group ES2):In addition to the maintenance of conventional intravenous anesthetics, esketamine 0.250 mg·kg^-1·min^-1 was continuously infused intravenously to the suture.
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1.Both male and female patients are eligible. 2.Age range: 65 to 79 years. 3.Body mass index (BMI): 18 kg/m^2 < BMI < 30 kg/m^2. 4.American Society of Anesthesiologists (ASA) physical status classification: I to III. 5.Elderly patients scheduled to undergo thoracoscopic lobectomy or segmentectomy for lung cancer.
Exclusion criteria
Exclusion criteria: 1.History of cardiovascular diseases, including hypertension, coronary heart disease, and arrhythmia. 2.Preoperative endocrine disorders or severe hepatic/renal dysfunction. 3.History of stroke within the past 3 months. 4.Allergy or contraindication to propofol, opioids, ketamine, or their components. 5.History of psychiatric disorders. 6.Participation in any drug clinical trial within the last 3 months. 7.Those who are allergic to or contraindicated to propofol, opioids, ketamine and other drugs and their drug components.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Intraoperative Esketamine Dose;Visual Analog Scale (VAS) scores during activity (coughing) at 6 hours after surgery ;The incidence of dizziness within 48 hours after surgery;Time from the end of surgery to tracheal extubation;post-anesthesia care unit (PACU) stay duration;Cumulative postoperative oxycodone dose at 48h;The incidence of postoperative nausea and vomiting (PONV) within 48 hours after surgery, ;The incidence of delirium within 48 hours after surgery;The incidence of hallucinations within 48 hours after surgery;The incidence of nightmares within 48 hours after surgery;The incidence of somnolence within 48 hours after surgery;The incidence of constipation within 48 hours after surgery;Patient satisfaction after surgery;Visual Analog Scale (VAS) scores during activity (coughing) at 12 hours postoperatively;Visual Analog Scale (VAS) scores during activity (coughing) at 24 hours postoperatively;Visual Analog Scale (VAS) scores during activity (coughing) at 48 hours postoperatively;Cumulative postoperative oxycodone dose at 24h;The Intraoperative Remifentanil Dose;The Intraoperative Sufentanil Dose;Total number of PCA pump presses s at postoperative 24h ;Number of effective PCA pump presses at postoperative 24h ;Total number of PCA pump presses s at postoperative 48h ;Number of effective PCA pump presses at postoperative 48h; | — |
Countries
China
Contacts
Public ContactMa Yanhui
Xuanwu Hospital, Capital Medical University
Outcome results
None listed